The 'winning combinations' we have now, like 'string, valor, ss, gaze' for a melee fighter seem like they are still the best.
For one thing, they have a ton of new unique shields, and none is still as good as a stormshield...so....
And it will still suck to play a necro...the improvements to damage theyre making is offset by the fact that 'Slain monsters rest in peace' now, a mod which most people will try to take advantage of.