Need Help: Install Diablo Twice Or Clean It

I think it would notice D2 entries in the Registry, and not allow a reinstall...

One nifty thing you could use, is C3PO. It's a D2hackit/Maphack type of deal, that has a loader option to load with/without R2D2 loaded. Very cool. The only downside to it, is that you can't use any D2Loader plugins while using it.