The one major weakness of William Birkin is he is way too slow, except for his Cerberus form.
The general tactics of fighting Mutated William goes like "Keep a good distance, Attack, Run around before he strikes." He usually makes large action before he strikes, for example, raising his arm.
As for the instant death pipe hit, I'm not too sure about since when I played RE2, I didn't die in one hit... but then I was playing the PC version. Either way, it is not hard at all to dodge the hit, not to mention his first form is quite weak (at least, he ran away after a few shot).
And I wasn't even talking about Dante, I was talking about how a human would take on William.
As for Dante? Well, there are many different ways Dante can defeat him. (Talking DMC3 now) For firearm, the easiest choice would Ebony & Ivory with Kalina Ann (dual pistols and a Rocket Launcher, and there's no need to worry about ammos).
As for his devil arms? Well.. it's a bit tough, but any weapon would work. I'll go with Agni & Rudra + Nevan.
Style-wise, having Trickster is not necessary, because it is easy enough to dodge William's attack as it is. (Quick Roll and Air Hike are enough)
SwordMaster and Royal Guard would be the best for this battle. SwordMaster will end this fight so much faster, while Royal Guard will... render Dante untouchable.
As I've mentioned, the general tactic is not to stay too close, and not too far because William will jump (not that it is a problem for Dante). At a mid distance, it is free shot with Kalina Ann. To be honest, I think William will go down with several Rockets... no matter which form he is in. (also, this is mutation, not transformation, so he cannot go back to his previous form)
Dante can certainly do this with the Rocket Launcher, too. With his Ebony & Ivory... he can rain bullets onto William. While E&I works well in any distance, I'd say Dante will get close just for argument's sake.
(Assumming SwordMaster)
Equipped with the electric guitar Nevan, the first move will be "Reverb Shock," charged into the enemy with lightning along with electric bats. Then just for style, he will Tune-up right in front of William. (Tune-up will stun any nearby enemies, and can be followed up with varies combo)
After the Tune up, Dante can get into Jam Session, summoning a swarm of bats to charge at his foe.
And those he would do just for the style (and it will fill up his devil gauge). To get serious, Dante will go into Devil Trigger and execute Air Raid. Flying around in the air and shooting Thunder Bolt, and occasionally go personal with Vortex, dealing massive damage.
That's only with one weapon though. Dante can switch Firearm/Devilarm at any given time as long as he is not executing a move. So, at anytime, he can switch to Agni & Rudra and call upon the power of Fire and Wind. The most powerful moves from A&R would be Aerial Cross, Crossed Swords, Sky Dance, Twister/Tempest. At a mid/far distance, Dante can also use Crawler, which call fire up from the ground toward the enemies.
Twister/Tempest is when Dante spins his swords really fast, and create a vortex of flame and wind to destroy anything in the area.
You might say that Dante will get hit sometimes. I really doubt that he would, due to the slowness of William, but even if Dante gets hit, it will not be the deadly attacks (since they are predictable). With the fast health regeneration in Nevan Devil Trigger, those lost health will be regained in no time.
(Assuming Royal Guard)
With Royal Guard, Dante will lose a few fancy moves such as Twister/Tempest, Sky Dance, Crossed Sword, Distortion etc. But he gains the blocking ability. and it is not JUST blocking, but it is block and charge.
Dante can block any attack with Royal Guard in DMC3. From the small sickle attack to huge-tentacle-whole-screen-wipe-out attack (which appear in DMC3). While the attack is blocked, the energy will be charged, and Dante can release it back to the them when he wants to, doing huge damage. The harder they hit... the harder they will get it back.
Also, there is the Ultimate move, which is blocking technique. But instead of JUST blocking, it blocks and ABSORBS the energy, and in turns healing Dante himself.
Except for Air Raid, all these moves do not require Devil Gauge at all and can be execute at any time (most are ground only) with any weapon.
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